A compound represented by the formula: [wherein R¹ is methoxy, methylthio, ethyl, etc.; R⁵ and R⁶ are each independently cyclopropylmethyl, (4-tetrahydropyranyl)methyl, etc.; and two of R⁴⁰, R⁴¹ and R⁴² are C_1-6 alkoxy while the remaining one is methoxymethyl, etc.], a salt thereof, or a hydrate of the foregoing. This compound has excellent antagonism against corticotropin-releasing factor receptor.