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发明授权
CN100584460C 不对称(转移)氢化催化剂 失效 - 权利终止 转让

不对称(转移)氢化催化剂
摘要：
一种用通式MLaXbSc代表的不对称(转移)氢化用催化剂，其中M是过渡金属，选自铑和钌，X是反离子，S是配体，a介于0.5～3，b和c各自独立地介于0～2，L是一种手性配体，具有通式(1)，其中Cn连同2个O-原子和P-原子一起形成一个取代或未取代的具有2～4个碳原子的环，R1和R2各自独立地代表H、任选取代的烷基、芳基、烷芳基或芳烷基基团，或者可与它们所键合的N-原子一起形成一个(杂环的)环。以及一种烯键不饱和化合物、酮、亚胺或肟衍生物在氢给体和催化剂存在下的不对称(转移)氢化方法，其中采用一种由通式MLaXbSc代表的催化剂，其中M是过渡金属，选自铑、铱和钌，X是反离子，S是配体，a介于0.5～3，b和c各自独立地介于0～2，其特征在于，L是一种手性配体，具有通式(1)，其中Cn连同2个O-原子和P-原子一起形成一个取代或未取代的具有2～4个碳原子的环；R1和R2按上面的规定。
摘要（英）：

Catalyst for the asymmetric (transfer) hydrogenation represented by the formula MLaXbSc, where M is a transition metal, to be chosen from rhodium and ruthenium, and X is a counter ion and S is a ligand, a ranges from 0.5 to 3 and b anc c, each independently, range from 0 to 2, and L is a chiral ligand having the formula (1), where Cn together with the two 2 O-atoms and the P-atom forms a substituted or non-substituted ring with 2-4 C-atoms, R<1> and R<2> each independently represent H, an optionally substituted alkyl, aryl, alkaryl or aralkyl group or may form a (heterocyclic) ring together with the N-atom to which they are bound. And a process for the asymmetric (transfer) hydrogenation of an olefinically unsaturated compound, ketone, imine or oxime derivate in the presence of a hydrogen donor and of a catalyst, use being made of a catalyst represented by formula MLaXbSc, where M is a transition metal, to be chosen from rhodium, iridium and ruthenium, X I a counter ion, S is a ligand, a ranges from 0.5 to 3 and b and c range from 0 to 2, and L is a chiral ligand having the formula (1), where Cn together with the two 2 O-atoms and the P-atom forms a substituted or non-substituted ring with 2-4 C-atoms; and R<1> and R<2> are as defined above.

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