The invention discloses a realizing method of a separate talk of an interphone module in one terminal with wireless interphone module, which includes the following steps: a separate talk frequency band is arranged, which is different from the joint talk frequency band and the information including the separate talk frequency band is stored into the sender terminal and the receiver terminal that have separate conversation; the data traffic between the sender terminal and the receiver terminal is turned on and the data traffic is registered into the communication network; and the interphone module in the sender terminal and the interphone module in the receiver terminal can have separate conversation by the separate conversation frequency band. By adopting the invention, with little cost, the wireless interphone part in the wireless interphone mobile phone can realize the separate talk, thus being characterized by convenient and simple operation.