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CN100596296C 一种烟酸的制备方法 失效 - 权利终止

一种烟酸的制备方法
摘要：
本发明是关于烟酸的一种制备方法。在液相中，由钴盐、锰盐和溴化物催化，含氧气体氧化3-烷基吡啶获得烟酸，产率81.%，纯度98%以上。体系中加入自由基引发剂，反应优选在温度170～180℃，1.5MPa的压力下进行。溶剂是含有少量小分子有机酸的芳香性卤代烃，反应中不腐蚀设备，反应后经过活性白土脱色或者蒸馏处理可以重复使用。本方法制备烟酸不污染环境，是一种适合工业化生产的方法。
摘要（英）：

The present invention is nicotinic acid preparing process. Inside liquid phase and under the catalysis of Co salt, Mn salt and bromide, 3-alkyl pyridine is oxidized with oxygen containing gas to obtain nicotinic acid of purity over 98 % in the yield of 81 %. The reaction system has free radical initiator added and the reaction is performed preferably at temperature of 170-180 deg.c and pressure of1.5 MPa. The solvent is aromatic alkyl hydride containing small amount of small molecular weight organic acid and has no corrosion to the apparatus in reaction, and the reacted solvent is decolorizedwith active white clay or distilled for reuse. The nicotinic acid preparing process of the present invention has no environmental pollution and is suitable for industrial production.

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