The invention belongs to the field of polymer material preparation and particularly relates to a pyridine-blocked polyetheretherketone and a polyetheretherketone containing pyridine side groups, a method for preparing the two polyetheretherketones and the use of the two polyetheretherketones in preparing polymer microspheres. The pyridine-blocked polyetheretherketone is obtained by the reaction between a fluorine-blocked polyetheretherketone containing trifluoromethyl side groups and a blocked monophenol monomer containing pyridyl groups. The polyetheretherketone containing pyridine side groups is obtained by the copolymerization of a bisphenol monomer containing pyridyl groups, a 4, 4'-difluorobenzophenone monomer and a bisphenol A. The two polyetheretherketones exhibit good solubility and functionality, and interact with other polymers containing special groups through non-covalent bonds to produce a micelle precursor. The micelle precursor is further subjected to cross-linking reaction to produce polyetheretherketone microspheres with stable structure. The polyetheretherketone microsphere is further used to produce functional macromolecular microsphere materials which meet the application demands in various high-tech fields.