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CN101054410B 鸡IBDVVP2蛋白中和性B细胞抗原表位Ⅲ及其应用 失效 - 权利终止

鸡IBDVVP2蛋白中和性B细胞抗原表位Ⅲ及其应用
摘要：
本发明属于分子免疫学领域，主要涉及鸡传染性法氏囊病病毒IBDV VP2蛋白的多肽片断，特别是涉及VP2蛋白中组成B细胞抗原表位的多肽片断，本发明同时涉及IBDV VP2蛋白中和性B细胞抗原表位在制备免疫原、免疫动物、产生免疫保护上的应用以及在检测抗鸡传染性法氏囊病病毒IBDV抗体或抗鸡传染性法氏囊病病毒IBDV多肽抗体上的应用。由鸡IBDV VP2蛋白中和性B细胞抗原表位设计的免疫原或疫苗免疫动物机体后能够产生针对IBDV的中和性抗体，并能够在体内或体外中和IBDV，阻止病毒感染动物机体，鸡IBDV VP2蛋白中和性B细胞抗原表位表位疫苗能够预防鸡IBD经典毒株、超强毒株或/和变异毒株的感染。
摘要（英）：

The present invention belongs to molecular immunology field, mainly relating to chicken infectious bursal disease virus IBDV VP2 polypeptide fragment, more specificly relating to B cell antigen epitope polypeptide fragment in VP2 protein. The present invention also relates to IBDV VP2 protein neutrality and uses of B cell antigen epitope in preparing immunogen, immune animal, immune protection and uses for detecting antibody of resisting chicken infectious bursal disease virus IBDV or polypeptide of chicken infectious bursal disease virus IBDV. Animal is immunized by immunogen or vaccine designed according to B cell antigen epitope which can neutralize chicken IBDV VP2 protein and can produce antibody for neutralizing IBDV in vitro or vivo, so the immunogen can prevent virus infection to animal. Chicken IBDV VP2 protein neutralized B cell antigen epitope vaccine can prevent infection of chicken IBD classic toxic strain, superstrong toxic strain or/ and variant toxic strain.

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