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发明公开
CN101057144A 用于评价乳腺癌预后的方法和组合物 无效 - 撤回

用于评价乳腺癌预后的方法和组合物
摘要：
提供了用于评价乳腺癌患者，特别是早期阶段乳腺癌患者预后的方法和组合物。本发明的方法包括检测身体样品中至少一种，更特别的是至少两种生物标记的表达，其中生物标记或生物标记的组合的超表达预示乳腺癌预后。在某些实施方案中，所述的身体样品为乳腺组织样品，特别是原发性乳腺肿瘤样品。本发明的生物标记为蛋白质和/或基因，其超表达预示良好或差的癌症预后。所关注的生物标记包括参与细胞周期调节、DNA复制、转录、信号传导、细胞增殖、侵入、蛋白水解或转移的蛋白质和基因。在本发明的某些方面中，使用生物标记－特异性抗体在蛋白质水平上或使用核酸杂交技术在核酸水平上检测所关注的生物标记的超表达。
摘要（英）：

Methods and computer program products for evaluating and optimizing one or more markers for use in establishing a prognosis for a patient suffering from a disease are provided. More particularly, the methods include steps for systematically evaluating a number of features that may be extracted from an image of a body sample, such as a histological slide, that has been exposed to one or more biomarkers so as to establish a prognostic decision rule based on one or more of the extracted features such that the decision rule yields a prognosis that is optimally predictive of actual patient outcome. Thus, the methods and computer program products provided yield optimally predictive prognoses to assist clinicians in developing strategies for effective patient care management.

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