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发明公开
CN101065100A 作为清凉剂的噻吩并嘧啶 失效 - 权利终止

作为清凉剂的噻吩并嘧啶
摘要：
式(I)化合物使哺乳动物如人产生局部清爽或凉爽感觉的用途，其中R1为任选被C1－4烷基取代的C4－6亚烷基链；R2为＝NH、－NH2或－OH；R3为任选被羟基、苯基或5－或6－元杂环基团(如呋喃基或N－咪唑基)封端的C1－5烷基且R4为H；或R3和R4一起形成C3－5亚烷基链。
摘要（英）：

Use of a compound of formula (I) where R<1> is a C4-6 alkylene linkage optionally substituted by a C1-4alkyl group; R<2> is =NH, -NH2 or -OH; R<3> is C1-5 alkyl optionally terminated by a hydroxy, phenyl or a 5- or 6- membered heterocyclic group such as furyl or N-imidazolyl and R<4> is H; or R<3> and R<4> together form a C3-5 alkylene linkage; to produce a topical refreshing or cooling sensation in a mammal such as a human.

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