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发明授权
CN101066990B 具有人群广谱性的抗肿瘤CTL表位肽 失效 - 权利终止

具有人群广谱性的抗肿瘤CTL表位肽
摘要：
本发明公开了一种具有人群广谱性的抗肿瘤CTL表位肽，该肽由九个天然氨基酸残基组成，其序列为：Ala-Leu-Tyr-Gly-Asp-Ile-Asp-Ala-Val(ALYGDIDAV丙氨酸-亮氨酸-酪氨酸-甘氨酸-天冬氨酸-异亮氨酸-天冬氨酸-丙氨酸-缬氨酸)。选择COX-2(环氧合酶-2)作为目的抗原，氨基酸序列引自GENEBANK。本发明的优点在于：1、突破MHC多态性限制，能同时被HLA-A2和HLA-A3提呈；2、对上皮组织肿瘤具有普遍适应性；3、对其它表达COX-2的肿瘤也同样适用。
摘要（英）：

The present invention discloses one kind of antitumor CTL epitope peptide comprising nine natural amino acid residues in the sequence of Ala-Leu-Tyr-Gly-Asp-Ile-Asp-Ala-Val (ALYGDIDAV). The antitumor CTL epitope peptide has COX-2 as the target antigen, and amino acid sequence quoted from GENEBANK. The present invention has the advantages of no limitation of MHC polymorphism and capacity of being submitted simultaneously by HLA-A2 and HLA-A3, effectiveness on epithelium tumors, and effectiveness on other tumor expressing COX-2.

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