The invention relates to a medicinal composition for treating vasculitis, preparation and the process for preparing same, wherein the preparing process comprises the steps of extracting achyranthes and cyathula root, scrophularia root and Dendrobium nobile with water, alcohol depositing twice, water depositing, filtering, obtaining filtrate A, subjecting honeysuckle flower herb to ethanol extraction and water deposition, adjusting pH of the filtrate, passing through macroscopic adsorption resin column, eluting with water, concentrating the eluent, filtering, obtaining filtrate B, merging A and B, filtering and concentrating the filtrate. the composition of the invention can be used as active constituent to obtain any of the pharmacologically acceptable dose forms by charging pharmaceutically acceptable auxiliary materials.