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发明授权
CN101104682B 一种异端基遥爪聚乙二醇及其制备方法 失效 - 权利终止

一种异端基遥爪聚乙二醇及其制备方法
摘要：
本发明是一种异端基遥爪聚乙二醇即异端基遥爪PEO及其制备方法。本发明首先利用乙烯基乙醚对二醇HO-(CH2)n-OH，n＝2-10或HO-(CH2-CH2-O)n-H，n＝1-5的一端羟基进行保护，将得到的产物和金属钾反应制备成小分子引发剂后，成功地引发环氧乙烷开环聚合制得两端分别为保护羟基和“活性”羟基的PEO。然后，将“活性”羟基先进行修饰，再将另一端羟基的保护基团在酸性环境中脱除，制得异端基遥爪PEO；或者还可以继续对PEO两端的官能团进行选择性修饰，制得多种组合的异端基遥爪PEO。
摘要（英）：

The invention provides a telechelic polyethylene glycol with variant end-group, namely a variant end-group telechelic PEO and a preparation method of the variant end-group telechelic PEO. First, the invention uses ethyl vinyl ether to protect hydroxyl at one end of diol HO-(CH2)n-OH,n=2-10 or HO-(CH2-CH2-O)n-H,n=1-5. Then the production obtained through the above process has reaction with metal potassium to prepare small molecule initiator which can successfully initiate the ring-opening polymerization of ethylene oxide to make the PEO whose two ends are respectively protective hydroxyl and active hydroxyl. The active hydroxyl is modified first, and then the protective group at the other end of the hydroxyl is removed in the acid environment to make the variant end-group telechelic PEO; or the functional groups at the two ends of the PEO can be modified selectively to make various combination of the variant end-group telechelic PEO.

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