The present invention relates to a method of sulphuration-floatation combining processing zinc kiln dreg. Making the material zinc kiln dreg grinded in a dry manner to the texture -0.074 mm, which covers 30 to 50 wt percent, and adding the simple substance sulfur of 3 to 5 wt percent, and microwave heating and sulphuration for 5 to 8 minutes under 250 DEG C to 500 DEG C, and then holding wet typegrinding, and the pulp concentration is 50 to 60 percent, and when the texture is grinded to -0.074 covering 60 to 75wt percent, and then holding the floatation art. Complexly recovering copper and lead mixed concentrate, the zinc concentrate and the iron concentrate from the zinc kiln dreg. The invention adopts the manner of combining the low temperature sulphuration and floatation art, which changes the mineral surface activity; and the floatation property of the sulfide is good, and the adding amount of the sulfides is few, and the invention has small energy consumption with little environmental pollution.