The invention discloses a manufacturing process obtaining the skin-imitated effect from the clothing or the finished product, which includes the processes such as superficial treatment, spraying and baking, softening treatment, etc., the process selectively sprays the polyurethane on the clothing or the finished product, to cause the effect like washing the used jeans. The invention is characterized by strong skin-imitated feeling and nature old feeling, and is colorful and diversiform, more particularly suits for the fast manufacture with a plurality of varieties in limited quantities of thecompetitive clothing industry nowadays.