The invention discloses a long-effective implantation agent of thymic pentapeptide in the drug agent domain, which is characterized by the following: adopting thymic pentapeptide as treating active material and biologically decomposed material as base; making the appearance as fine rob shape or cylinder shape; injecting or surgerying to transplant into body; releasing drug completely without surgery and fetching; obtaining high-packing rate and drug-carrying quantity to approach constant speed to release one to several months; reducing the medical cost; improving the compliance for patients. The invention has simple preparing technique and high safety, which projects he clinical treatment superiority and good applying prospect.