A hemming work system of body panel for vehicle, including: guiding orbit, which is arranged with an unilateralism cycle path from a feeding part to a removing part; a transportation device, which moves along the guiding orbit, and unloads the body panel from a transportation vehicle on the feeding part, and loads the body panel being hemmed to a removing car on the removing part; a plurality of hemming devices, which correspond to a plurality of vehicles, and are installed on the above of the guiding orbit along the moving path of the transportation device in order; a controller, which controls the work of the transportation device, and confirms whether the type of the body panel and the type of the hemming device are same or not, just when the types of them match with each other, the controller restart the hemming device to implement hemming work program. Thus, a plurality of body panels corresponding to each vehicle move along a single guiding orbit, so as to improve work efficiency.