The invention discloses a laser cutting method to cut fragile material base, which comprises the following steps: utilizing a cracker to form pre-cutting line on the fragile material base; using laser beam to heat the fragile material base along the pre-cutting line; adopting gas lower than zero deg. c to cool the heat fragile material base without penetrating water among bases to influence the normal work to improve the cutting standard rate; cracking the fragile material base along the pre-cutting line. The invention uses gas not to remain residual drip on the surface of base, which needn't clean the base after cutting due to using gas as cooling flow, therefore reducing the manufacturing cost.