利索-全球专利检索

  1. 登录
  2. 注册
发明公开
CN101152561A Lefty蛋白在抑制器官纤维化病变中的应用 无效 - 撤回

Lefty蛋白在抑制器官纤维化病变中的应用
摘要：
本发明公开了一种Lefty蛋白在抑制器官纤维化病变中的应用，该Lefty蛋白作为制备拮抗TGF－β、Nodal、BMP、p38MAPK信号通路的药物在基础研究中的应用和将Lefty蛋白作为制备治疗或预防在肝、肾、肺、心肌、皮肤等器官和组织纤维化病变的药物中的应用。抑制纤维化疾病相关信号通路(如TGF－β/Smad、Nodal信号通路)和活化具有抑制纤维化的相关蛋白水解酶类(如MMP、明胶酶等)两大方面。是极具潜在临床应用价值的生物制剂，还可为进一步探讨纤维化疾病的发生机制提供帮助。
摘要（英）：

The invention discloses the application of a Lefty protein in prohibiting fibering pathologic change of organs, in basic research on preparing the medicine for antagonizing TGF-beta, Nodal, BMP, p38MAPK signal pathways, and in preparing the medicine for curing or preventing fibering pathologic change of organs and tissues of liver, kidney, lung, cardiac muscle, skin, etc. The invention has the functions of prohibiting signal pathways (such as TGF-beta/Smad, Nodal signal pathways) related to fibering diseases and activating protein hydrolytic ferment (such as MMP, gelatingase, etc) capable of prohibiting fibering, is a biological preparation with great potential clinical application value, and can help to further probe into the occurring mechanism of fibering diseases.

0/0