The invention discloses a swine fever virus epitope vaccine and a method of preparing the vaccine. An amino acid residue sequence of active protein of the vaccine comprises 6 copies of or more than 6 copies of the amino acid residue sequence of the sequence 1. In the swine fever virus epitope vaccine provided by the invention, the active protein selects very conservative neutralizing epitope to remove the surrounding sequences of the neutralizing epitope, and does not comprise any other virus components or other virus protein sequences; GS is regarded as a connecting peptide, which can more focus on displaying the epitope function, so that the body fluid response to the epitope can be more concentrated and intense.