The present invention discloses a stable sodium pyruvate (NaPyr) medical aqueous solution. It contains 20-1200 mM of sodium pyruvate and sodium pyruvate stabilizing agent. The described stabilizing agent is hydrogen ions making pH be 3.5-4.9 or sodium chloride (NaCl) capable of providing sodium ions (Na+) whose concentration at least is 20mM. Said invention also discloses various solutions formedby using said stable NaPyr medical aqueous solution, such as simple NaPyr aqueous solution, high permeation NaCl/NaPyr aqueous solution, compound physiological saline, NaPyr modified electrolyte solution or above-mentioned solutions simultaneously containing colloid, for example hydroxyethyl starch and peritoneal dialysis liquor or blood filtration displacement solution. The above-mentioned thesesolutions can be extensively applicable to clinical shock resuscitation, venous liquid therapy, and can be used for correcting severe metabolic acidosis and curing important organ dysfunction, and making renal failure replacement therapy.