The invention discloses an oral liquid for preventing hydrophobia and the preparation method, which takes Chinese goldthread, nux vomica, cantharis, fingernail, toenail, hairs of woman, peach shoot, locust tree shoot and mulberry shoot as materials and prepared with extra care by certain processes. The invention has advantages of using poisons as antidotes, effective rabies virus removing, good preventing effect, non toxic and side-effect and sequela, non need of rabies vaccine, easy administration, easy material acquiring, simple making and low cost, and is the novel pure Chinese drugs preparation for preventing hydrophobia. The invention is particularly suitable for patients can not be inoculated with rabies vaccine timely in vast rural areas and remote mountainous areas.