The invention relates to a drug gradient zero-grade implantation controlled release drug delivery device and the preparation method thereof; the drug delivery device takes the controlled release polymer as a frame, the top surface and the bottom surface are formed by bonding of the insoluble polymer, that is, the release resistant materials, and the middle drug is radially distributed according to the gradient. The axial two sides of the drug deliver system are sealed by the polymer, and then the drug is released radially and two-dimensionally; the radial drug concentration difference is obtained by the change of the times of printing and spraying the drug-carrying adhesives, the peripheral drug release area is big, the spraying times are less, and the drug concentration is low; the drug release area of the central area is small, the spraying times are more, and the drug concentration is high. The drug concentration takes the gradient distribution and the drug release rate is constant. The technique has simple preparation, high degree of automation and good reproducibility.