A gas-liquid sterilization and purification device includes a box (1) with an inlet and an outlet (6, 7), a fan (2) installed in the box and a UVC UV lamp (3); the top plate (10) of the box is a hinged cover plate; the sterilization cavity of the box consists of a plurality of sterilization units (4) in parallel, is a rectangular box, with an air inlet (8) on the left side and an air outlet (9) on the right side; the air inlet and the air outlet are staggered up and down; the inlets and outlets of adjacent sterilization units are jointed; a bend filter mesh (5) separates the inlet and the outlet of the inner cavity of the box; the filter mesh is coated with TiO2 coating; a lamp hole corresponding to the UV lamp is opened on the filter mesh; the UV lamp is installed in the box and goes through the lamp hole. The invention is a gas-liquid sterilization and purification device which has the advantages of keeping the gas to be sterilized close to the TiO2 coating, keeping the gas to stay on the coating for long, and good sterilization effect, can very conveniently change the sterilization capability according to the requirements for sterilization space and environment pollution, with good anti-leakage and sealing effect.