The invention discloses a MIMO pre-coding method with a plurality of subchannels and a pre-coding signal receiving method; in a sender and a receiver, m pre-coding vectors which are the same with that of the receiver are determined in a predefined code book for constructing an original pre-coding matrix V, wherein, m is the number of the subchannels; the Givens angles between two subchannels in the subchannels are acquired, and a Givens pre-coding matrix G is constructed according to all the required Givens angles. The sender uses the product of the original pre-coding matrix V and the Givenspre-coding matrix G as a sending pre-coding matrix and sends signals by using the sending pre-coding matrix; the receiver uses a conjugate transpose matrix of the product of a signal channel matrix H, the original pre-coding matrix V and the Givens pre-coding matrix G as a receiving weight matrix and implements signal receiving and detecting by using the receiving weight matrix. The method of theinvention can greatly reduce the interference among subchannels and improve system performance.