The invention discloses a flexibly pre-printed paper box, a manufacture method and a manufacture equipment thereof; the paper box has a box body consisting of a printed sheet, corrugated paper, inner paper and in some cases core paper; color patterns on the printed sheet are flexibly printed on the printed sheet before the paper box is manufactured. The manufacture method consists of a manufacture method of flexibly printed paper sheet and a manufacture method of the paper box; firstly the color patterns are manufactured on the printed sheet with a rotary flexographic press; then bright oil is applied, and then the printed sheet, the corrugated paper and the inner paper are made into the paper box by adopting a corrugated paper manufacture device; some paper box also comprises the core paper. The manufacture device consists of the rotary flexoographic press, the corrugated paper manufacture equipment and a die-cutting machine. Adopting the method and the equipment of the invention, the manufactured paper box is green and environmental protective, nice in printed patterns, high in compressive strength, convenient in lifting and low in reject rate; compared with paper boxes which are printed with offset printing and directly with flexible plate of the same quality requirement, the paper box of the invention has lower cost.