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CN101219988A 一种4,4′－二取代基－2,2′－联吡啶的合成方法 失效 - 权利终止 转让

一种4,4′－二取代基－2,2′－联吡啶的合成方法
摘要：
本发明公开了一种4，4′－二取代基－2，2′－联吡啶的合成方法，主要是将4－取代基吡啶与金属催化剂按100∶0.2～40的重量比混合，然后置于能够加热加压的可密闭反应器中，以惰性气体吹气鼓泡5～30分钟，将反应器密闭，加热至140～300℃，在搅拌条件下反应2～350小时，冷却、过滤、旋蒸、重结晶后即可得到目标产品4，4′－二取代基－2，2′－联吡啶。本发明方法简单、效率高、生产成本低，适合大规模的工业化生产。
摘要（英）：

The invention discloses a method for synthesizing 4, 4'-disubstituted-2, 2'-bipyridine, which mainly mixes a 4-substituent pyridine and a metal catalyst according to a weight ratio of 100: 0.2 to 40. The mixture is put in a closable reactor which can be heated and pressurized, which is bubbled for 5 to 30 minutes with inert gases; then the reactor is closed to be heated to a temperature of 140 to 300 DEG C, reacted for 2 to 350 hours under a condition of stirring; after cooling, filtering, rotating steaming and re-crystallization, a target product 4, 4'-disubstituted-2, 2'-bipyridine can be obtained. The method of the invention is simple with the advantages of high efficiency and low cost, thus being suitable for large-scale industrial production.

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