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发明授权
CN101230109B 磺化酰化6-羧基壳聚糖及其制备方法 失效 - 权利终止

磺化酰化6-羧基壳聚糖及其制备方法
摘要：
本发明公开了一种由(I)表示的壳聚糖衍生物；其中：R表示-H、-SO3H、或-COR1；R′表示-CH2OH、-COOH、-CH2OSO3H、或-CH2OCOR1；以及，R1代表C1～4低级烷基；本发明还涉及该化合物的制备方法。具有操作、工艺简单，产物及中间产物的净化不需透析等繁琐操作；另外，还具有反应速度快且易于控制，该壳聚糖衍生物具有的生物相容性和很强抗凝血性能。
摘要（英）：

The invention discloses a heparin substitute expressed provided with the formula (1) of sulphonated and acidylated 6-carboxy-chitosan or the salt thereof. R expresses -H, -SO3H, or -COR<1>; R1 expresses -CH2OH, -COOH, -CH2OSO3H, or -CH2OCOR<1>; and R<1> represents C1-4 lower alkyl. The invention also relates to a preparation method of the compound. The invention has the advantages that the operation and the process are simple, and the dialysis and other tedious operation are not required for the purification of the product and the intermediate product; in addition, the reaction velocity is fast and easy to be controlled, and the sulphonated and acidylated 6-carboxy-chitosan is provided with biocompatibility and strong anticoagulant performance.

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