Embodiments of the invention address deficiencies of the art in respect to hypertransport-based switching for multi-CPU systems and provide a method, system and computer program product for flexibly configurable multi-CPU supported hypertransport switching. In one embodiment of the invention, a hypertransport switching data processing system can be provided. The system can include a CPU and at least two I/O bridges. Each I/O bridge can provide a communications path for data driven to a corresponding peripheral device from the CPU. Notably, the system can include a flexibly configurable hypertransport switch. The switch can include a first configuration adapting the CPU to both of the I/O bridges, and a second configuration adapting the CPU to a first one of the I/O bridges and a second CPU to a second one of the I/O bridges.