The invention relates to an adriamycin liposome as well as a preparation method, belonging to the technical field of pharmacy, which is characterized in that: the components of the liposome provided by the invention can be the mixture of a portion free of phospholipid or a portion with part phospholipid and polyethylene glycol-diacid glyceride; the added polyethylene glycol-diacid glyceride can significantly reduce the internal heat energy produced when the liposome is formed, thus increasing the stability of the liposome. Therefore, the adriamycin liposome has the advantages of significantlyimproved stability, long-time storage under normal temperature and practical industrial production.