The invention discloses a blotting membrane plate as well as the application thereof in the material crystallization purification, the blotting membrane plate is a supporting flat sheet membrane, which is characterized in that a polymer membrane which originally contains target substances and adheres on the surface of a supporting body is provided with blots left after the target substances are cleaned. The membrane plate serves as a crystal board to guide the target material to crystallize and precipitate thereon in the supercritical CO2 fluid solvent extraction process, so as to realize thepurpose of the crystallization purification. Compared with the traditional solvent crystallization method, the method has the advantages that the crystallization time is short, the efficiency is high, and the crystal purity above 99 percent is high, thereby being applicable to the preparation of ultrapure materials.