The invention relates to an ion exchange regeneration method. The method adopts an automatic-circulating pipe system and a related valve group, integrates automatic control techniques, thereby achieving the automatic operations of the following steps in the regeneration process: a washing step, a sheath liquid regeneration step, an acid regeneration step, a first pure water washing step, a base transformation step and a second pure water washing step. Additionally, the method has optimum design of parameters such as overall pH value, time and electrical conductivity in the transition points between individual steps. The method can improve regeneration effect and system operation efficiency and reduce operation cost.