The present invention relates generally to a multi-faceted approach to the control of plant pathogens including plant pests. More particularly, the present invention relates to plants such as crop plants genetically modified to produce at least two pesticidal or pestistatic agents which in at least one agent is a serine proteinase inhibitor or precursor thereof from the solanaceaefamily and at least one other is a non-serine proteinase inhibitor slected from the list a Bt protein, a member of the CRY family, a VIP and a defensin, and wherein said exhibits resistance or reduced susceptibility to a pest.