The invention provides a far infrared ray antibiotic natural mulberry silk quilt which is characterized in that the mulberry silk quilt consists of a quilt cover and a quilt inner; the quilt inner takes natural hollow mulberry silk which is treated and irradiated by far infrared ray and added with an additive containing the compositions of nano-silver and antiseptic in the hollow as raw material, a layered structure is woven in a way of crossing, the quilt inner is arranged in the quilt cover to form the quilt; the quilt inner can slowly release silver ions to provide antibiotic functions and release far infrared ray permanently, which does not reduce along with the increase of using times.