The invention discloses a vehicle air conditioning refrigeration system leak-stopping agent which has low cost and no toxicity, is environment-friendly, can prevent refrigerant from leaking from connecting parts and pipeline sand holes, avoid the waste of the refrigerant, reduce the maintenance times of the on-board air conditioning, and decrease the maintenance cost of the vehicle. Alkyl silicone oil with 0.1 to 70 percent of the total weight, alkoxyl silicone oil with 0.5 to 70 percent of the total weight, hydroxyl-terminated silicone oil with 0.1 to 50 percent of the total weight, organicamine curing agent with 0.1 to 10 percent of the total weight, and organic tin with 0.1 to 10 percent of the total weight are taken as raw materials, and the leak-stopping agent can be produced by adding the raw materials into a dry stirring tank and evenly stirring the raw materials.