The invention discloses an external-application medicine for treating hepatic disease, which belongs to a prepared medicine featured in special physical property. The invention is prepared of the following materials by weight ratio: the herbal pieces prepared for decoction of citrus fruit, trigone, euphorbia kansui, betel palm, cassia twig, mulberry, rhubarb, baikal skullcap root, magnolia officinalis, choisy, herba artemisiae capillaries, yuanhu, peach kernel, green tangerine orange peel, and salvia miltiorrhiza; the above materials are mixed evenly after being clearly selected, are dried in60-70 DEG C for 6-8 hours, and are mechanically crushed into medicine powder, are screened by a 80 mesh sieve; the medicine powder and medical Vaseline are mixed by the ratio of 1 to 1 to 5, are stirred into paste, and are cooled for standby. The invention with such design are applied externally on the herbal points with convenient usage, the medicine can be absorbed through skin, the medical effect is quick, the dilutedness and the harmful side effect of the oral medicine in gastrointestinal tract can be avoided; the first passing effect of the liver is avoided, and the external-application medicine is applicable for patients suffering acute and chronic viral hepatitis, alcoholic hepatitis, and fatty hepatitis, etc., is in particular applicable for the chronic hepatic patients of which the vital energy and blood are weak, and viscera function is maladjusted due to long-time medicine taking.