The invention provides a synthetic method for taurolidine and a medicinal preparation thereof. The method comprises the preparing steps: adopting cysteamine hydrochloride as raw material to carry outthe reaction of chloridization, azide and hydrogenization, preparing the target product taurolidine by condensation reaction with formaldehyde. The synthetic route avoids the shortages of multistep process of the original synthetic route which consumes large amount of and complex chemical materials and is easy to cause side effect. By adopting the technique of the invention, the prepared taurolidine has higher purity, and the preparation made is more stable and has exacter healing effect.