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发明公开
CN101278999A 九里香叶总黄酮在制备治疗糖尿病药物中的应用 无效 - 撤回

九里香叶总黄酮在制备治疗糖尿病药物中的应用
摘要：
本发明公开了九里香叶总黄酮在制备治疗糖尿病药物中的应用。从中药九里香叶中提取分离的九里香叶总黄酮，主要含有5，7，3′，4′－四甲氧基黄酮、5，7，3′，4′，5′－五甲氧基黄酮、5，6，7，3′，4′－五甲氧基黄酮、5，6，7，3′，4′，5′－六甲氧基黄酮、7－羟基－5，3′，4′－三甲氧基黄酮。动物实验结果表明，九里香叶总黄酮能够明显降低T2DM大鼠的血糖，改善T2DM大鼠的脂代谢紊乱，升高T2DM大鼠血清中C－肽水平和胰岛素含量，提高胰岛β细胞分泌指数，降低胰岛素抵抗指数，改善IR，降低T2DM大鼠的血清MDA含量，升高SOD活性，降低T2DM大鼠的血清IL－1β、IL－6、TNF－α含量。证明九里香叶总黄酮对糖尿病具有显著的治疗作用。
摘要（英）：

The invention discloses an application of flavonoids of murraya paniculata in the preparation of medicine for treating diabetes mellitus. The flavonoids are extracted from the murraya paniculata leaf and essentially comprise 5, 7, 3', 4'-tetramethoxy flavonoid, 5, 7, 3', 4', 5'-pentamethoxyl flavonoid, 5, 6, 7, 3', 4'- pentamethoxyl flavonoid, 5, 6, 7, 3', 4', 5'-hexamethyl flavonoid, and 7-hydroxyl-5, 3', 4'-trimethyl flavonoid. The results of the animal experiments show that the flavonoids of murraya paniculata can remarkably reduce the blood glucose in T2DM rats, improve the disturbance of lipid metabolism of the T2DM rats, increase the C-peptide level and the content of insulin in the serum of the T2DM rats, improve the excretion index of Beta cells of the insulin and IR, reduce the insulin resistance index, the MDA content in the blood serum of the T2DM rats and the contents of IL-1Beta, IL-6 and TNF-Alpha in the serum of the T2DM rats, and improve SOD activity. The test proves that the flavonoids of murraya paniculata have remarkable efficacy on the diabetes mellitus.

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