The invention discloses a medical combination for treating injury of the spleen and the stomach of children caused by improper diet and a preparation method and a quality control method thereof. The raw medicines of the medicine combination of the invention comprise: radix astragali, rhizome of large-headed atractylodes, dried citrus peel, tuber of dwarf lilyturf, root of large-flowered skullcap,whitethorn and Chinese radish seed. The preparation method is characterized in that: water is added for decoction for twice to three times, 1 to 3 hours each time, decocted liquid is combined and filtered, and filtration is condensed to paste with a relative density of 1.01 to 1.05 (measured at 55 to 70 DEG C), then the paste is refrigerated for 30 to 60 hours and filtered. 250 to 350 parts by weight of refined honey and 0.4 to 0.7 parts by weight of sorbic acid are added to the filtration, and water is used for regulating the total amount to 800 to 1200 parts by volume, the mixture is stirred evenly and kept standing for 30 to 60 hours, supernatant fluid is taken, filled and sterilized, and the medicine combination is obtained. High performance liquid chromatography is used in the invention for measuring the content of hesperidin. The medicine combination of the invention has relatively good curative effects for treating injury of the spleen and the stomach of children caused by improper diet.