The invention discloses a comprehensive disposal method for municipal solid wastes, which comprises the following steps: 1) the wastes are pre-sorted to separately get primary wastes, plastic wastes, fiber wastes and brick wastes; 2) after the treatment of rapid biological fermentation of the primary wastes, degraded wastes are formed; 3) after the secondary sorting of the degraded wastes, non-organics in the degraded wastes are removed; the sorted degraded wastes are obtained; 4) the sorted degraded wastes are ground; after-mature compost treatment is carried out to obtain mature wastes; 5) fertilizer making treatment is carried out for the mature wastes to obtain organic fertilizer. After the method of the invention is used for treating the municipal solid wastes, the harmless level is improved and the effective use of resource is fully realized.