The invention discloses an automatic dust removal purifier with high voltage, belonging to the technical field of dust removal purifiers. The technical problem that needs to be solved is to provide a dust removal purifier with high voltage which can remove the deposited matter in machines in time. The technical proposal for solving the technical problem is that: the dust removal purifier includesa shell, a rotating shaft, a rotary electrode, a rotating dust remover, a motor, a reducer, a high voltage DC power and an outer insulation layer; the middle section of the shell is provided with an upper bearing pedestal back plate and a lower bearing pedestal back plate of the rotating shaft; the upper section of the rotating shaft is arranged on the upper bearing pedestal back plate, the lowerend thereof is installed on the lower bearing pedestal back plate, the lower section thereof is provided with a support plate of the dust remover; the motor and the reducer are arranged in the shell,and the reducer is connected on the rotating shaft; the rotary electrode is arranged on the rotating shaft; the rotating dust remover is mounted on the upper bearing pedestal back plate and the support plate of the dust remover; the DC high voltage is applied between the rotary electrode and the shell. The automatic dust removal purifier with high voltage is applicable to the dust removal in industrial and mining establishments, offices, public places and households and has the advantages that the purifier can eliminate the deposited matter on the inner walls and has safe usage.