The invention discloses an automatic dust removal purifier with high voltage, including a shell, a shaft of a dust remover, an electrode, the dust remover, a motor, a reducer, a linear motion convertor, a high voltage DC power and an outer insulation layer; the motor, the reducer and the linear motion convertor are arranged in the upper section of the shell, an output shaft of the motor is connected with an input shaft of the reducer, an output shaft of the reducer is connected with an input shaft of the linear motion convertor and an output shaft of the linear motion convertor is connected with the shaft of the dust remover; the electrode is arranged on the shaft of the dust remover; the dust remover includes an upper end plate, a lower end plate, a connecting post and a circular ring, the upper end plate and the lower end plate are arranged on the shaft of the dust remover, the connecting post is installed between the upper end plate and the lower end plate, and the circular ring ismounted outside the connecting post; the high voltage DC power is arranged in the upper section of the shell, and high voltage is applied between the electrode and the shell; the outer insulation layer is arranged outside the shell. The automatic dust removal purifier with high voltage is applicable to the dust removal in industrial and mining establishments, offices, public places and householdsand has the advantage that the motor can be started at any time for removing the deposited matter on inner walls in a state of continuous running.