The invention discloses a polynucleotide which is capable of transforming nutrilit Alpha-H second polypeptide and encoding the polypeptide. The invention also provides a method for producing the polypeptide by the recombinant technique and the application of the polypeptide to the treatment aspect. The treatment comprises the stimulation of the healing of wound, the curing of neurological disorder, the curing of the paropsia, the curing of kidney and liver dysfunction and the stimulation of the embryo generation and the vessel formation. The invention also discloses an antagonist aiming at the polypeptide and the application of the antagonist taken as a curing agent to cure the tumor disease. The invention also discloses a method for detecting the level of the change in the polypeptide and for encoding the mutation of the nucleic acid sequence of the polypeptide.