The invention relates to an enteric preparation of thiazolidinedione metal salt class medicine which is orally taken and used for treating metabolic syndromes, for example diabetes, and also relates to the preparation method of the enteric preparation. The enteric preparation of the invention is composed of two parts, namely a) a medicinal core composed of thiazolidinedione metal salt class medicine and medicinally available accessory; and b) an enteric coating or an enteric hollow capsule. The preparation method of the enteric preparation is the corresponding one of the enteric preparation methods which include crushing, screening, weighing and mixing of the original accessory, making the accessory into grains, filling ordinary capsules after the enteric capsule filling or enteric coating wrapping or wrapping the enteric coating after tabletting.