The present invention discloses a health-care granule which is prepared from ingredients of the following weight percent: 65 to 90 percent of traditional Chinese medicinal extract, and 10 to 35 percent of yam flour; wherein, the traditional Chinese medicinal extract is extracted from red common stonecrop herb, prepared radix-polygoni multiflori, radix astragali, root of herbaceous peony, rhizoma polygonati, Chinese yam, medlar and kudzu root. The present invention also discloses a preparation method of the health-care granule, which comprises the following steps: preparing the traditional Chinese medicines of all herbs, the yam flour, the Chinese medicinal extract, and the health-care granule according to certain weight portions. The health-care granule is prepared from pure Chinese medicine; the raw materials are natural and environmentally friendly, and have no toxic side effects. Moreover, the health-care granule has the functions of benefiting qi, enriching blood, nourishing yin, invigorating kidney, dispelling evils, advocating rightness, nursing heart, and so on, and can be used for preparing health-care capsules which are used for enhancing the immunity and alleviating physical fatigue.