The invention provides a connection structure of a cable management frame, which comprises a main frame body, a supporting frame, a supporting slider, a supporting fastener and two installation parts. The main frame body includes a sliding bush installed on the supporting frame; each of the two ends of the main frame body connects to an installation part; both ends of the supporting frame connectto the supporting slider and the supporting fastener respectively, the installation part and the supporting fastener are equipped with a stopping button respectively, the sliding bush which can rotate in a certain angle is mounted on the left or right position of the sliding assembly freely by the installation parts on both ends of the main frame body, and the supporting slider and the sliding fastener according to the left side and right side of the sliding assembly is a slide connection and permanent connection respectively. Thus the main frame body can spread along with the stretching of the sliding assembly and can slide on the supporting frame.