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发明授权
CN101348514B 一种从面包海星提取的海星皂苷类化合物的用途 失效 - 权利终止

一种从面包海星提取的海星皂苷类化合物的用途
摘要：
本发明提供了一种海星皂苷类化合物，分子式为C57H93O28SNa，化学名称为(20R，2R，23S，24S)-6α-O-{β-D-吡喃岩藻糖基-(1→2)-α-L-吡喃阿拉伯糖基-(1→4)-[β-D-吡喃奎诺糖基-(1→2)]-β-D-吡喃奎诺糖基-(1→3)-β-D-吡喃葡萄糖基}-22，23-环氧-20-羟基-24-甲基-5α-胆甾-9(11)-烯-3β-硫酸钠。体外抗肿瘤试验表明，该化合物对C6大鼠恶性胶质瘤细胞以及U87MG、U251MG、BT325和SHG44四种人恶性胶质瘤细胞有明显的抑制作用，而不影响原代培养的人神经胶质细胞生长。该化合物可望用于制备治疗胶质瘤的药物。
摘要（英）：

The invention provides a compound of starfish saponin having a molecular formula of C57H93O28SNa, and a chemical name of sodium(20R,22R23S,24S)-6Alpha-O-{Beta-D-fucopyranosyl-(1,2)-Alpha-L-arabinopyranosyl-(1,4)-[Beta-D-quinovopyranosyl-(1,2)]-Beta-D-qinovopyranosyl-(1, 3)-Beta-D-glucopyranosyl}-22,23-epoxy-20-hydroxy-24-methyl-5Alpha-cholest-9(11)-en-3Beta-yl-sulfate, hereafter referred to as EHMC. The compound is an anti-tumor monomer extracted from starfish, as the biological bread in the sea, and is characterized in the application thereof in the preparation of drugs against colloid tumors. Anti-tumor researches in vitro imply that the compound has significant inhibiting effects on glioma of C6 rat as well as four human gliomas including U87MG,U251MG,BT325 and SHG44, without any influence on growth of cultured primitive human neuroglial cells. The compound is expected to be applied to the preparation of drugs against gliomas.

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