The invention relates to two successively applied medicinal preparations for treating condyloma acuminatum. The technical problem to be solved by the invention is to provide the two successively applied medicinal preparations for treating the condyloma acuminatum which can not damage normal tissues, are convenient to use and are effective. The compositions of a transdermal absorption type medicinal preparation are 30 to 80 weight percent of trichloroacetic acid homolog, 2 weight percent of water-soluble azone compound, 1 weight percent of menthol and the balance being water, wherein the azonecompound comprises azone, Laurocapram, novel azone and derivatives of the azone, the Laurocapram and the novel azone and the trichloroacetic acid homolog comprises a trichloroacetic acid, a glacial acetic acid and derivatives of the trichloroacetic acid and the glacial acetic acid. The compositions of a coating medicinal preparation are 0.2 weight percent of glycyrrhetic acid, 2 weight percent ofwater-soluble azone compound, 10 weight percent of urea, 2 weight percent of nano-silver water solution and the balance being water. By utilization of the two medicinal preparations to coat affected parts, viruses can be eliminated, immunity can be strengthened and recrudescence can be prevented, thus the expected aims are achieved in practice.