The invention discloses a method for processing a main cable saddle of a suspension bridge. A side span (1) and a midspan (2) of the main cable saddle are respectively processed, then a bolt (3) is used to connect the side span and the midspan, and a joint surface of the side span (1) and the midspan (2) is provided with a positioning pin hole (6). The method guarantees the consistency of the sizeof a rope groove after the side span (1) and the midspan (2) are butted, has no alternate edges, high butting accuracy and small error, unifies processing reference, has low requirement on processingequipment, is more convenient for clamping and calibration of workpieces, is easy to guarantee processing accuracy, and improves processing efficiency.