The invention discloses a drug composition for treating otitis media, the drug composition is composed of raw materials with the following proportion by weight: 3 to 25 parts of amur corktree bark, 5 to 50 parts of honeysuckle flower, 3 to 35 parts of common anemarrhena rhizome, 2 to 20 parts of borneol, 0.125 to 15 parts of erythromycin enteric-coated tablets, 1 to 3 parts of raw pricklyash peel and 20 to 50 parts of sesame aroma oil, the amur corktree bark, the honeysuckle flower, the common anemarrhena rhizome, the borneol, the erythromycin enteric-coated tablets and the raw pricklyash peel are respectively groundinto powder, evenly mixed, soaked in the sesame aroma oil, bottled and sealed to prepare oil solution. The use of the drug composition for treating patients with otitis media has short treatment time, low cost, high cure rate of more than 90 percent and no relapse.