The invention relates to a sand control completion structure of a horizontal well, which comprises a well wall and a sand control tube, wherein the well wall comprises an ascending section and a horizontal section. A sleeve is arranged on the ascending section of the wall; one end of the horizontal section close the ascending section is the butt end, while the end far away from the ascending section is the tip end; the angle between the horizontal section of the wall and the horizontal plane varies from 0 to 20 degrees; the sand control tube is positioned inside the horizontal section of the well wall and fixedly connected with the well wall; and the cavity between the sand control tube and the well wall is filled with glassy hollow granules. The sand control completion structure of the horizontal well has the advantages of easy realization of the well completion process and good well completion quality.