The invention discloses a method and a device for fluorescence endoscopic imaging. The technical scheme is as follows: a speckle image producing unit produces a speckle image; a light transmission unit is coupled with the speckle image producing unit, and one end of the light transmission unit can be inserted at an tissue to be tested inside a body; the light transmission unit focuses the speckleimage on the tissue to be tested through an object lens positioned at the end of the light transmission image to activate a fluorescence image, and reversely sends the fluorescence image out of the body; a light distribution unit separates the fluorescence image at the outer end of the light transmission unit from a light path; an image acquisition unit coupled with the light distribution unit records the fluorescence image; and an image analyzing and processing unit processes and analyzes the recorded fluorescence image. The method for fluorescence endoscopic imaging can conduct scatheless and high spatial resolution imaging on the tissue to be tested at a cell level in a wide-field way, the post-processing of data is easy, and the speed of imaging is high. The device for fluorescence endoscopic imaging is simple-structured and cost-effective.